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The Weinstein Laboratory

Transgenic Zebrafish

We have isolated a number of vascular- specific promoters and used them to drive the expression of green or red fluorescent proteins, "test" genes of interest, and transcriptional activators (for binary transgenesis) in transgenic fish (info on how we make transgenics). The fli-EGFP line also permits imaging of blood vessels in living adult fish, as shown below. Top: whole adult fli-EGFP transgenic fish. Bottom: close-up images of fin (left) and scales (middle and right) showing fluorescence is vascular-specific.

Close-up images of fin and scales showing fluorescence is vascular-specific.

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