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The Weinstein Laboratory

Science In The Weinstein Lab

The overall objective of the Weinstein Laboratory is to understand the cellular and molecular mechanisms responsible for the specification, patterning, and differentiation of blood vessels during vertebrate embryogenesis, using the zebrafish as an advantageous experimental model organism. Blood vessels are ubiquitous and vital components of all vertebrate animals, innervating and supplying every tissue and organ with oxygen, nutrients, and cellular and humoral factors. They have also become a subject of great clinical interest in recent years, particularly with the potential shown by antiangiogenic therapies for combating cancer. Many of the most important insights into mechanisms of blood vessel formation have come from developmental studies. The zebrafish, a small tropical freshwater fish, possesses a unique combination of features that make it particularly well suited for studying blood vessels.

Major aims of the laboratory include